Bioequivalence (2x2 crossover, exact TOST noncentral t, 80-125%) — calculate

Evaluates the exact power of the two one-sided tests (TOST) procedure using the noncentral t distribution (Phillips 1990; Julious 2004 Section 6.3, Eq 6.2 and 6.8). Matches sampleN.TOST in the PowerTOST package exactly.

Usage

calculate_bioequivalence(
  cv,
  alpha,
  power,
  theta0 = 1,
  margin_low = 0.8,
  margin_high = 1.25
)

Arguments

cv: Intra-subject coefficient of variation
alpha: Type I error (one-sided per test, default 0.05)
power: Target power (default 0.80)
theta0: Anticipated T/R geometric mean ratio (default 1.0)
margin_low: Lower equivalence margin (default 0.80)
margin_high: Upper equivalence margin (default 1.25)

Value

List with sample size results consumed by as_sample_size_result()